Funding Acknowledgement and Department of Health Disclaimer: Dr Edward Carlton is funded by a National Institute for Health Research (NIHR), Advanced Fellowship (NIHR300068) for this research project. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

Bristol Randomised Trials Collaboration Acknowledgement: This study was designed and delivered in collaboration with the Bristol Randomised Trials Collaboration (BRTC), a UKCRC registered clinical trials unit which, as part of the Bristol Trials Centre, is in receipt of National Institute for Health Research CTU support funding.

Sponsor Acknowledgement: This study is sponsored by North Bristol NHS Trust.

REDCap Acknowledgement: Study data are collected and managed using REDCap (Research Electronic Data Capture, Harris PA, et al. J Biomed Inform. 2009 Apr;42(2):377-81) hosted at the University of Bristol.

Please note: The content of this website is produced from RELIEF documentation which has been reviewed by the Health Research Authority, ‘South Central – Oxford C Research Ethics Committee’ and ‘Scotland A Research Ethics Committee’, who have provided approval for this study to be conducted in the NHS.