Funding Acknowledgement and Department of Health Disclaimer: Dr Edward Carlton, Advanced Fellowship NIHR300068, is funded by the NIHR for this research project. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR, NHS or the UK Department of Health and Social Care.

Bristol Randomised Trials Collaboration Acknowledgement: This study was designed and delivered in collaboration with the Bristol Trials Centre, a UKCRC registered clinical trials unit, which is in receipt of National Institute for Health Research CTU support funding.

Sponsor Acknowledgement: This study is sponsored by North Bristol NHS Trust.

REDCap Acknowledgement: Study data are collected and managed using REDCap (Research Electronic Data Capture, Harris PA, et al. J Biomed Inform. 2009 Apr;42(2):377-81) hosted at the University of Bristol.

Please note: The content of this website is produced from RELIEF documentation which has been reviewed by the Health Research Authority, ‘South Central – Oxford C Research Ethics Committee’ and ‘Scotland A Research Ethics Committee’, who have provided approval for this study to be conducted in the NHS.